CIRO can make a decision to impose a temporary suspension (halt) of trading in a security of a publicly-listed company. Trading halts are implemented to ensure a fair and orderly market. CIRO is the national self-regulatory organization which oversees all investment dealers and trading activity on debt and equity marketplaces in Canada.
SOURCE Canadian Investment Regulatory Organization (CIRO) – Halts/Resumptions
View original content: http://www.newswire.ca/en/releases/archive/October2025/24/c1478.html
Biotech is a dynamic industry that is driving scientific advances and innovation in healthcare. In Canada, the biotech sector is home to companies pursuing cutting-edge therapies and medical technologies.
Read on to learn what’s been driving these Canadian biotech firms.
Eupraxia Pharmaceuticals is developing clinical candidates that employ its DiffuSphere technology, which delivers treatments to the targeted tissues.
The company’s candidates are currently EP-104GI for eosinophilic esophagitis and EP-104IAR for knee osteoarthritis, and it is exploring the use of its technology for other active compounds as well.
Eupraxia added EP-104GI to its pipeline through its acquisition of EpiPharma Therapeutics in late 2023. The company has continued to advance the treatment through clinical trials in 2025 and released multiple rounds of positive data from its Phase 1b/2a trial cohorts.
In July, Eupraxia dosed its first patient after advancing its investigation to Phase 2b trials based on safety and efficacy data from the earlier Phase 2a patient cohorts. Top-line results from the Phase 2b study are anticipated in the second half of 2026.
In September, the company shared data from the highest-dose cohort of the still ongoing Phase 1b/2a trials, reporting that the group saw the largest improvements so far.
Bright Minds Biosciences is developing novel serotonin agonists targeting neurocircuit abnormalities linked to neuropsychiatric disorders and epilepsy, designing next-generation treatments that aim to retain the therapeutic benefits of psychedelics while minimizing side effects.
Its lead candidate, BMB-101, a selective 5-HT2C receptor agonist, has shown encouraging preclinical efficacy by stopping seizures in an epilepsy mouse model, evaluated jointly with Firefly Neuroscience (NASDAQ:AIFF).
The company’s stock surged nearly 1,500 percent in October 2024 following H. Lundbeck’s acquisition announcement of a competitor focused on similar targets. Strengthening its epilepsy expertise, Bright Minds expanded its scientific advisory board in early 2025 by adding five leaders in the field.
Ongoing clinical progress and strategic growth initiatives position Bright Minds as a promising contender in the neuropsychiatric treatment landscape.
Hemostemix is a clinical-stage biotech company focused on developing autologous stem cell therapies, meaning the treatments use a patient’s own cells to theoretically enhance safety and efficacy.
Its main product, ACP-01, is an autologous cell therapy designed to promote tissue repair and regeneration in areas affected by diseases, including a range of heart diseases.
The company announced its first advanced sales orders for ACP-01 in Q1 2025 and has been working to expand internationally and attract new investment.
Hemostemix secured the regulatory green light for commercial sales in Florida after the state passed Senate Bill 1768. The bill creates a framework in which healthcare providers can administer stem cell therapies that had not yet been approved by the US Food and Drug Administration (FDA) but meet the bill’s guidelines.
The company now offers commercial ACP-01 treatments for ischemic pain in the state under the name VesCell, with sales forecasted to reach C$22.5 million in 2026. Operational plans target cash flow positivity by Q4 2026, supported by a growing physician network and commercial pipeline.
Additionally, Hemostemix is currently collaborating with Firefly Neuroscience on a Phase 1 clinical trial of ACP-01 for vascular dementia.
NervGen is a clinical-stage Canadian biotechnology company that focuses on developing innovative treatments to enable the nervous system to repair itself following damage from injury or disease.
The company’s core technology targets a mechanism that hinders nervous system repair. When the nervous system is damaged, chondroitin sulfate proteoglycans (CSPG) form a “scar.” Initially, CSPGs help contain damage, but their long-term interaction with the PTPσ receptor inhibits repair.
NervGen’s lead drug candidate, NVG-291, is designed to relieve these inhibitory effects to promote nervous system repair. It received fast-track designation from the US FDA.
NervGen is advancing NVG-291 in a Phase 1b/2a clinical trial for spinal cord injury (SCI) and reported positive data from the chronic cohort in June.
NVG-300, a newer preclinical candidate, is being evaluated for ischemic stroke and SCI.
Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.
A group that includes activist investor Jana Partners and NFL player Travis Kelce says it has accumulated one of the largest ownership stakes in Six Flags Entertainment and intends to press the company’s leadership on ways to improve the struggling amusement park operator’s business.
Jana said Tuesday that the investor group now owns an economic interest of approximately 9% in Six Flags. The group plans to ‘engage’ with Six Flags’ management and board of directors to discuss ways to enhance shareholder value and improve visitors’ experience.
Shares in the Charlotte, North Carolina-based Six Flags surged 17.7% on the news. The shares added another 5.1% gain in after-hours trading. Even with Tuesday’s rally, the company’s shares are down about 47% so far this year.
Six Flags reported a loss of $319.4 million for the first half of the year. The company said attendance fell 9% in the three months that ended June 29, due partly to bad weather and a ‘challenged consumer’ in most of the markets it operates in.
The investor group also includes consumer executive Glenn Murphy and technology executive Dave Habiger.
Kelce, tight end for the Kansas City Chiefs, said in a statement that he grew up going to Six Flags amusement parks.
‘The chance to help make Six Flags special for the next generation is one I couldn’t pass up,’ he said.
The American cattle ranching industry is blasting President Donald Trump’s proposal to purchase beef from Argentina in an effort to lower supermarket beef prices.
“This plan only creates chaos at a critical time of the year for American cattle producers, while doing nothing to lower grocery store prices,” Colin Woodall, CEO of the National Cattlemen’s Beef Association, said in a statement Monday.
Wyoming-based cattle operation Meriwether Farms addressed Trump directly in a social media post Monday.
“We love you and support you — but your suggestion to buy beef from Argentina to stabilize beef prices would be an absolute betrayal to the American cattle rancher,” the farm wrote on X.
By midday Tuesday, the post had already received 4 million views. A representative for Meriwether Farms did not immediately respond to a request for comment.
Trump floated purchasing beef from the South American nation Sunday aboard Air Force One to push down U.S. beef prices by increasing the overall supply.
‘We would buy some beef from Argentina,’ he told reporters, ‘If we do that, that will bring our beef prices down.’
Beef prices have hit record highs this year, according to data from the Bureau of Labor Statistics,fueled in part by depleted herd counts and steady demand from U.S. consumers.
Card-reading contact lenses, X-ray poker tables, trays of poker chips that read cards, hacked shuffling machines that predict hands. The technology alleged to have been used to execute a multistate, rigged poker operation sounds like it’s straight out of Hollywood.
And those were only some of the gadgets that authorities say were used to swindle millions of dollars from unsuspecting victims through rigged, high-dollar, underground poker games over more than five years.
A sprawling indictment unsealed Thursday by the U.S. attorney for the Eastern District of New York charged Chauncey Billups, the head coach of the NBA’s Portland Trail Blazers, and Damon Jones, a former NBA player, along with members of the Mafia and dozens of other defendants, with being part of a conspiracy.
The victims were “at the mercy of concealed technology, including rigged shuffling machines and specially designed contacts lenses and sunglasses to read the backs of playing cards, which ensured that the victims would lose big,” U.S. Attorney Joseph Nocella of Brooklyn said in a statement.
Cheating at poker is as old as poker itself. But today, wearable tech and nano-cameras are putting even upstanding poker players on their guard.
The defendants used “special contact lenses or eyeglasses that could read pre-marked cards,” Nocella said at a news conference announcing the indictments.
He also showed a photo of an X-ray table that “could read cards face down on the table … because of the X-ray technology.”
An X-ray poker table in an image from defendant Robert Stroud’s iCloud account.U.S. Justice Department
“Defendants used other cheating technologies, such as poker chip tray analyzers, which is a poker chip tray that secretly reads cards using a hidden camera,” he said.
And while marking poker cards so they are visible only with special eyewear is an old trick, new radio-frequency identification and infrared technologies have ramped up the sophistication levels.
Technically speaking, many of the devices involved in the alleged scam authorities detailed Thursday are relatively cheap to manufacture, said Sal Piacente, a gaming security consultant.
By the time they reach their customers, however, the cost of industrial shufflers or tables can easily approach $100,000, once distributors and middlemen are factored in.
“You could make a lucrative career buying this stuff,” Piacente said.
Casino and gaming security consultants told NBC News that the alleged scheme was possible only because the games were underground. In backrooms, there was none of the surveillance tech that reputable casinos use to catch players cheating.
“A lot of the features which made this scheme so successful would have been ID’d a lot sooner, or very quickly, in a traditional regulated gaming environment,” said Ian Messenger, a former U.K. law enforcement officer and founder and CEO of the Association of Certified Gaming Compliance Specialists.
More than any other tech, it was the reprogramming of the industrial card shufflers — identified in charging documents as Deckmate-brand machines — that authorities said was key to the alleged game rigging.
A DeckMate 2 shuffler taken apart on a table in an image from defendant Shane Hennen’s iCloud account. U.S. Justice Department
Deckmates are not sold directly to the public — though many used ones can be found for sale online. The ones at the high-dollar games cited in the indictment could read cards and predict which player had the best hand. Neither Deckmate nor its parent company, Light & Wonder, were implicated in any way in Thursday’s indictments.
A spokesman for Light & Wonder told NBC News in a statement that the company was aware of reports about the charges against people but said they were not affiliated with the company.
“We sell and lease our automatic card shufflers and other gaming products and services only to licensed casinos and other licensed gaming establishments,” said Andy Fouché, the company’s vice president of communications. “We will cooperate in any law enforcement investigation related to this indictment.”
Reprogramming shufflers is not a new trick. In 2023, hackers at the Black Hat security conference in Las Vegas presented research showing how to hack a Deckmate shuffler and use it to cheat.
The rigged shuffler machines would transmit information about the players’ hands to an off-site “operator,” according to prosecutors.
The computer program showing information transmitted by the rigged shuffling machine in an image from defendant Shane Hennen’s iCloud account. U.S. Justice Department
The operator would then communicate the information to someone else at the table, dubbed the “quarterback.” The victim was known as the “fish.”
Here, the high-tech gadgets met the low-tech of a card game.
The quarterback might touch the $1,000 poker chip or tap his chin or touch his black chips to indicate who at the table had the best hand.
Text messages obtained by prosecutors also appear to show defendants concerned that a fish would leave the table if he lost too many hands.
“Guys please let him win a hand he’s in for 40k in 40 minutes he will leave if he gets no traction,” read one text message released by authorities.
But according to Messenger, the consultant, it was not the tech that made the alleged scheme so successful for so long. What set it apart was the level of communication.
For example, he said, the card information had to be seamlessly passed from the dealing machines to an off-site operator and back to a person back at the table, all without alerting the fish.
“The piece that made this so successful was the coordination, not the technology,” he said.
Over a decade ago, Sen. Ted Cruz, R-Texas, predicted that healthcare premiums would skyrocket, even in the face of subsidies put into effect under Obamacare that were meant to bring them down.
Today, the ballooning of those premiums and their accompanying subsidies are at the center of the 22-day shutdown that looks poised to get longer still.
‘Despite Obamacare subsidies, many Americans will still be paying higher premiums in 2014 as a result of Obamacare,’ Cruz said in 2013, referring to the Affordable Care Act (ACA).
In his 2013 floor speech, Cruz pointed to research from Avik Roy, a healthcare researcher who, at the time, was a senior fellow at the Manhattan Institute. Roy’s research made the case that subsidies passed by the Obama administration would do little to stop government-backed healthcare plans from growing more expensive over time or competing effectively with non-government-backed plans.
But even those forecasts have paled in comparison to the costs of the government’s emergency response to the COVID-19 pandemic.
The subsidies under Obamacare have vastly expanded in recent years. An emergency provision included in President Joe Biden’s 2021 American Rescue Plan widened the range of eligible applicants as a response to the global pandemic.
Now that those COVID-era provisions are set to sunset at the end of 2025, an expiration date set by Democrats themselves, Democrats are voicing alarm that Obamacare policyholders will have to shoulder the costs of health insurance without the enhanced supplemental aid.
According to the Committee for a Responsible Federal Budget, a nonpartisan think tank that focuses on fiscal policy, continuing the expanded credits could cost upwards of $30 billion annually. Findings by KFF, a healthcare policy group, say that over 90% of the 24 million Obamacare enrollees make use of the enhanced credits.
KFF analysis indicates that the enhanced premium tax credits saved subsidized enrollees an average of $705 last year.
Democrats in Congress, led by House Minority Leader Hakeem Jeffries, D-N.Y., and Senate Minority Leader Chuck Schumer, D-N.Y., have demanded some sort of extension to the already expanded COVID-era subsidies as a condition for passing spending legislation to end the current government shutdown, which is now the longest full shutdown in history.
Republicans, who maintain that the subsidies are completely unrelated to government funding considerations, have said lawmakers will address the subsidies when the government is open again.
The most conservative members in Congress have said cutting back on the subsidies is key to returning the government to pre-COVID levels of funding.
Lawmakers in the Senate have voted 11 times on a short-term spending extension meant to keep the government open through Nov. 21 but have so far failed to move past the gridlock over the enhanced premium tax credits.
Cruz did not immediately respond to Fox News Digital’s request for comment.
President Donald Trump met with NATO Secretary-General Mark Rutte Wednesday — days after Ukrainian President Volodymyr Zelenskyy visited the White House andafter calling off a meeting with Russian President Vladimir Putin.
‘We canceled the meeting with President Putin,’ Trump told reporters in the Oval Office with Rutte Wednesday. ‘It just it didn’t feel right to me. It didn’t feel like we were going to get to the place we have to get. So I canceled it. But we’ll do it in the future.’
Trump also shed insight into why he isn’t interested in arming Ukraine with Tomahawk missiles, after indicating earlier in October he might do so.
‘There is a tremendous learning curve with the Tomahawk. It’s a very powerful weapon, very accurate weapon,’ Trump said. ‘And maybe that’s what makes it so complex. But it will take a year. It takes a year of intense training to learn how to use it, and we know how to use it. And we’re not going to be teaching other people. It will be just too far out into the future.’
Rutte said he visited the White House to discuss ways to end the war, although he said ‘no peace plan is on the table.’
‘That’s why I’m here — to dialog again with the president … how NATO, my colleagues and other colleagues in NATO can be of maximum support to get that,’ Rutte said.
NATO announced Tuesday that Rutte would visit Washington Wednesday, as Trump has said he wants to direct his focus on ending the conflict between Russia and Ukraine following the ceasefire deal in the Middle East.
Ahead of his arrival at the White House, Rutte said that Wednesday’s White House visit aimed to build on the momentum after securing the peace agreement in the Middle East.
‘I was texting with the president after an enormous success in Gaza, and we said, ‘Hey, let’s have a meeting in Washington to discuss how we now can deliver his vision of peace in Ukraine,’’ Rutte told reporters on Capitol Hill Wednesday after meeting with lawmakers, according to The New York Times.
‘I have total confidence in President Trump. He’s the only one who can get this done,’ Rutte said.
Rutte has visited the White House on several occasions during Trump’s second term, including in July and also in August after Trump’s Alaska summit with Putin. NATO has backed Ukraine since Russia first invaded, and has provided Kyiv with military equipment and other assistance since 2022.
In August, Rutte and other European leaders joined Zelenskyy in an effort to advance peace talks to end the war in Ukraine. At the time, Trump said that European nations would shoulder the bulk of the burden by providing Ukraine with security guarantees in an attempt to deter future aggression from Russia.
As part of these security guarantees, Ukraine has sought to become a member of NATO during the peace negotiations. However, Trump has routinely ruled that out as a possibility.
Meanwhile, Russia’s list of demands has historically included prohibiting Ukraine from ever joining NATO, and concessions on some land that previously belonged to Kyiv.
Additionally, Rutte’s meeting comes after Trump appeared to throw cold water on any hopes that the U.S. would arm Ukraine with Tomahawk missiles, like Trump had said he was considering doing days ahead of Zelenskyy’s visit.
‘I would much rather have them not need Tomahawks,’ Trump told reporters Friday. ‘I would much rather have the war be over to be honest, because we’re in it to get the war over.’
Additionally, Trump changed his tune on whether Ukraine would need to cede territory it had lost to Russia as part of a peace deal. Although Trump altered his position in September and said that Ukraine could secure back its lost territory, Trump reverted to his previously held position on the matter.
‘They can negotiate something later on down the line,’ Trump told reporters Sunday. ‘But I said cut and stop at the battle line. Go home. Stop fighting, stop killing people.’
The change in tone came after Trump spoke with Putin Thursday and the two were originally slated to meet this month in Budapest. However, plans for the meeting were scrapped after Secretary of State Marco Rubio’s call with Russian Foreign Minister Sergey Lavrov.
‘Secretary Rubio and Foreign Minister Lavrov had a productive call,’ a senior official said in a statement Tuesday to Fox News. ‘Therefore an additional in-person meeting between the Secretary and Foreign Minister is not necessary and there are no plans for President Trump to meet with President Putin in the near future.’
Meanwhile, Trump has recently cast doubt on whether Ukraine can defeat Russia.
‘They could still win it. I don’t think they will, but they could still win it,’ Trump told reporters Monday.
Fox News’ Gillian Turner and The Associated Press contributed to this report.
The Democrats, or Socialists, or whatever they are these days, are hopping mad over President Donald Trump’s construction of a ballroom in the East Wing of the White House, and while it may be their silliest freakout of the entire Trump era, it is also quite telling.
The ladies on ABC’s ‘The View’ were apoplectic when they saw images of demolition, a fairly ordinary way to begin renovations, at 1600 Pennsylvania Avenue. They echoed one-time resident Hillary Clinton’s complaint that Trump doesn’t own the White House, even taking to song about it.
What makes this argument so absurd, is that Trump is not building this ballroom for his personal use or glory. It’s not a vanity project. It is a long-considered addition to an executive home that lacked the capacity to hold large indoor events.
Trump, as has always been his wont, is looking to create grandeur, and that seems to be something to which leftists reflexively object.
Trump is obviously not the first president to renovate the White House. President Franklin Delano Roosevelt put in a swimming pool. His successor, President Harry Truman, practically gutted the place to add a balcony. President Nixon covered the swimming pool but added a bowling alley. Finally, President Obama transformed the tennis court into a basketball court.
Note that these are all changes that were made to serve the respective president’s personal taste or enjoyment, like a Roman emperor adding a water feature to his personal dining area.
What Trump is doing is completely different. The ballroom he is constructing will likely survive as a symbol of American power long after we are all gone. It will be, in a sense, our generation’s contribution to the people’s home.
Trump wants this venue, this symbol of America, to be grand and classically inspired, a timeless marble monument to a United States that emerged from the 20th century as the world’s only super power.
And in a way, this is part of what the left objects to, not just in regard to the White House project, but to Trump’s proposed new arch in Washington, D.C., and great statuaries of American heroes, not to mention the recent massive military parade.
In the post-Cold War era, part of America’s international style and sensibility was to be understated. Like the star quarterback who is also a model and a chess prodigy, we learned not to rub it in.
In that time, very little public art or architecture was done on a grand and classic scale, and in more recent times, our society has been so hellbent on taking statues and monuments down, that we gave little thought to putting them up.
Trump instinctively understands that in 2025, America may still be the world’s only superpower, but not by so hegemonic a distance as in the recent past. China, among others have been catching up, and the ‘aw, shucks’ attitude of the past needs some adjusting.
World leaders as well those on public White House tours should have their breath taken away when they walk into the presidential ballroom. Such displays are as old as nations themselves, from the pyramids to the Coliseum, it’s nothing to be ashamed of.
Though this expansion of the White House would be well worth taxpayer money, Trump has found a way to build it with private donations, as well as his own funds. Still the left is throwing a fit. Why?
Recent polling showed that only 36% of Democrats are very, or even just somewhat, proud of America. This being the case, it’s easy to understand why they object to building testaments to its power and glory.
What Democrats and socialists are really objecting to here is not that Trump’s ballroom celebrates himself, it’s that his ballroom unabashedly celebrates America.
Fifty years from now, when King George VII of Great Britain dines at the White House, people will little remember that it was built by Trump, even if all the gold leaf remains. By then, it will simply be a great piece of American architecture we can all be proud of.
Americans want and deserve a big, beautiful ballroom for their nation’s executive mansion, and there has never been a president more capable of delivering it than our real estate mogul-in-chief.
Liberals can stamp their feet in anger all they want. But the ballroom is going to be built, and eventually, most of them will come to appreciate it.
In today’s political environment, it is hard to envision important issues where Republicans and Democrats can find common ground. Protecting the safety and security of citizens from the Chinese Communist Party (CCP) is hopefully still that issue.
In recent years, we have seen growing agreement among lawmakers that the CCP is actively working against the security of the U.S. Whether through coercive trade practices, espionage, military aggression or technology theft, the CCP is intent on undermining American strength.
President Donald Trump has rightly identified our nation’s increased dependence on Chinese companies as a clear threat to national security. In response, he has taken action to rebuild our domestic industrial manufacturing bases. This is especially true in critical security industries like defense, nuclear development, pharmaceutical manufacturing and data center infrastructure.
The Trump administration should now look at medical devices. This lesser-known threat to American privacy and security lurks within our hospitals, health care facilities and even in the homes of everyday Americans. Used to treat patients, monitor patient health and inform medical decisions made by health care professionals, medical devices are critical tools used in the everyday care of our most vulnerable members of society.
It is no wonder, then, that medical devices made by Chinese companies not only have the potential to take advantage of that intimate access, but have already been shown to exploit those vulnerabilities to gain access to the personal, private data of American patients.
Just this month, it was reported that medical hardware from Shanghai-based United Imaging has been installed in some of the country’s top research labs. In some instances, these labs were even funded by the National Institutes of Health (NIH). Not only has United Imaging worked alongside the Chinese military and the state-run Chinese Academy of Sciences, according to the FBI, the company has also bribed employees working at an NIH-funded lab to backchannel non-public information about their research to United Imaging and the Chinese Academy of Sciences.
Earlier this year, the Food and Drug Administration (FDA) issued a warning about a patient monitor made by Chinese-based company Contec, specifically calling attention to a software backdoor on the device that once connected to the internet ‘begins gathering patient data, including personally identifiable information (PII) and protected health information (PHI), and exfiltrating (withdrawing) the data outside of the health care delivery environment.’
The Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency (CISA) followed up with its own report, saying that the backdoor enabled remote actors to engage in ‘remote code execution and device modification with the ability to alter its configuration.’
Far from being an idle threat, CISA explained that this vulnerability in a machine that monitors and displays critical information like electrocardiograms and blood pressure could result in life-or-death consequences: ‘This introduces risk to patient safety as a malfunctioning monitor could lead to improper responses to vital signs displayed by the device.’
Medical devices made by Chinese companies have quietly made their way into many hospitals and clinics in the United States, bringing with them hidden risks that are waiting to be abused by the CCP.
First, patient privacy is compromised when unknown actors can access and siphon the most sensitive and confidential data from every patient in America, undermining the very foundation of trust in our health care system.
Compounded with the fact that Chinese law compels Chinese companies to cooperate and share information with the CCP and that China prizes big data and is gathering information on individuals around the world, we can be assured that whatever private information is gathered on American patients is not in our national interest.
Second, we cannot trust that information siphoning will not escalate to more serious tactics that put patient lives at risk. Remote access to medical devices could result in real-world harm to patients if those devices were reconfigured to display false information that then led to unnecessary and harmful medical interventions.
Third, the U.S. healthcare system is becoming too dependent on Chinese companies to run our hospitals. It does not take much of a leap to think about what would happen if the CCP decided to cut off the supply of medical devices. Just like critical minerals, energy or military equipment, depending on Chinese companies for medical devices is a clear threat to American security.
What these threats amount to is that the U.S. can no longer blindly outsource medical devices – some of our most vital and sensitive equipment – to companies that operate at the behest of foreign adversarial governments like the CCP. It is critical that America has a domestic supply chain of medical devices.
Now is the time that lawmakers, both at the federal and state level, take this threat seriously and take meaningful steps to reduce the risks posed by these medical devices.
Protecting Americans from threats to their health and security should be an easy, bipartisan win.